Pubarche: development of axillary and pubic hair

Menarche: start of the first menstrual period

Growth spurt: it is the linear growth velocity in cm/year.

Adrenarche: it id an increase in secretion of the adrenal androgens. It occurs without any change in the secretion of the ACTH or cortisol.

Leptin is secreted by Fat cells

Oocyte maturity inhibiting factor is secreted by The follicular epithelium

Thecal cells are in the ovarian stroma

Follicular cells are stimulated to mature by FSH

pregnancy and lactation are the only things that interrupt the ovarian cycle.

Granulosa cells in the primary follicle connected to oocyte via gap junction and secret glycoproteins forming a clear layer called Zona pellucida

The fluid in the secondary follicle is secreted by granulosa cells

The dominant follicle appears at day 6

Primary oocye + granulosa cells= Corona Radiata

Eccentric oocyte + corona radiata= cumulus oophorus

At day 12 LH level begin to increase markedly 6:10 folds & reaches maximal level 16 hours before ovulation.

LH & FSH cause the primary oocyte ( in the Graafian follicle) to complete the meiosis 1 resulting in 2 daughters : Secondary oocyte & first polar body

The released ovum is surrounded by Zona pellucida and Corona radiata

LH is responsible for corpus luteum formation & secretion.

HCG is responsible for corpus luteum development.

The luteal phase is the only constant phase in time. (14 days)