GLP-1 weight loss drugs are producing the kind of adverse event data that is starting to break through to mainstream audiences, and the warning signs are coming from credible sources.

Harvard medical researcher Dr. David Sinclair told Joe Rogan that sudden blindness has doubled since the rollout of GLP-1 drugs, caused by a condition called NAION, a stroke-like event in the eye for which there is no treatment. Actress and neuroscientist Mayim Bialik disclosed her own severe experience publicly, including dehydration bad enough to require IV treatment at home. UK regulatory data shows 216 deaths and 18,000 severe reactions linked to GLP-1 drugs, with annual fatalities rising 300% between 2024 and 2025. The FDA's adverse event reporting system shows 228,350 total reported cases, 60,762 serious cases including deaths, and 1,631 deaths. A class action lawsuit over stomach paralysis is seeking $2 billion from Ozempic's manufacturer. A STAT News investigation into Life.MD, a major telehealth platform, found providers were expected to review 25 patient cases per hour based only on electronic forms, approximately two minutes per case, and were discouraged from asking medically relevant questions that might slow throughput.

However, there is a distinction between this conversation and the COVID vaccine mandate situation: GLP-1s are an adult choice driven by real medical risks of obesity, and microdosing approaches supervised by qualified practitioners appear to produce very different outcomes than the self-administered or high-dose telehealth model. The concern is whether patients are being properly informed of the risks and properly supervised during treatment.

@delbigtree

The COVID response may have produced the opposite of what its architects intended.

Denis Rancourt says the push for mass vaccination and emergency powers has left the public more skeptical, more resistant to mandates, and less willing to accept the same framework again.

He argues that U.S. vaccination policy is shaped in part by national-security planning for rapidly inoculating populations during a biological threat, and sees mRNA technology as especially attractive within that system because of how quickly it can be developed and deployed.

His concern is that the emergency infrastructure remains in place even as public trust has eroded.

@delbigtree

"An Inconvenient Study" has passed 130 million views and 17 festival awards worldwide. Del brought it to San Antonio on October 28th for a screening and Q&A alongside Dr. Bob Sears.

Sears has been a pediatrician for 30 years and has practiced through the full arc of the vaccine debate, from vaccinating all his patients on schedule to watching a large and growing portion of his practice choose to raise their children vaccine-free.

He describes the difference in health outcomes between his vaccinated and unvaccinated patients over three decades as night and day, and says the Henry Ford study that An Inconvenient Study is built around confirmed what he has watched play out in his office for years.

His waiting room is overflowing. He is turning new patients away due to a lack of capacity. He thinks vaccine hesitancy has moved well past a trend into a permanent cultural shift, and he would not be surprised if research showed that half of Americans no longer trust the CDC schedule.

@delbigtree

“I agree with all of the issues here. But when I came down to it, I just thought, ‘Would I walk away?’ I wouldn’t. And because of that, for my own integrity, I have to be true to my word.”

@delbigtree explains why he chose not to sign an open letter calling on President Trump and HHS Secretary Robert F. Kennedy Jr. to remove the mRNA platform.

The letter warns that health freedom voters “can and will walk away” if action is not taken. Del says he could not put his name behind that promise when he does not believe he would withdraw support from other actions he sees as meaningful progress.

“For my own integrity, I have to be true to my word.”
He points to investigations into SSRIs, changes in the food supply, efforts to reduce the childhood vaccine schedule, and a federal government now openly discussing vaccine injury and autism.

At the same time, Del says he hopes the pressure from the letter succeeds:

“I pray that this petition does everything that these beautiful, passionate individuals that are involved with it hope that it does, which is we get rid of one of the worst technologies that humanity has ever seen.”

@delbigtree

“Almost none of those have come to pass.”

Dr. @RobertWMalone says the MAHA movement has seen “failure after failure after failure to deliver” on priorities ranging from mRNA technology to glyphosate, and he argues that judging political leaders by their actions is more important than assuming what they intend to do.

Del Bigtree challenges him on what happens when critics inside the movement walk away from government altogether.

“You did resign. And now, really, we don’t have you inside of government.”

Their disagreement gets to a larger question now facing the health freedom movement: how hard do you push from the outside when the people trying to change the system from within are still navigating it?

@delbigtree

“The one thing we shouldn’t allow is some decision inside of our government to tear us apart as a movement.”

Del Bigtree says he is concerned about a growing strain of rhetoric inside the health freedom movement that appears to place vaccine-injured families and autism families in opposition to one another.

He points to claims that Robert F. Kennedy Jr. is prioritizing autism over people injured by COVID shots or other vaccines, including allegations attributed to unnamed people close to Kennedy.

Del says he is uncomfortable with that kind of hearsay and worries that the current fight over mRNA policy is beginning to fracture people who have spent years fighting many of the same battles.

Whatever disagreements exist over strategy or the administration’s actions, he argues that those disagreements should not turn one group of affected families against another.

@delbigtree

“I took a guy, and I threw him over the wall of a castle into a den of thieves and vampires, all in hopes that somehow he could make his way to the front gate to drop a drawbridge so that we could go in.”

@delbigtree pushes back against calls to abandon @RobertFKennedyJr. over the pace of change at HHS, arguing that Kennedy is battling an entrenched bureaucracy from within and needs more time.

“I’m not forgiving him. But I believe telling a voting body to pull your support of the only people that have ever had our backs on this issue, I don’t think that’s the right statement.”

@delbigtree

“We’re told that mammograms save lives. But when we look at the data... there is no increased survival tied to mammographic screening.”

Dr. Jennifer Simmons explains the concept of lead-time bias: screening may make it appear that a woman “survived” longer after diagnosis simply because the cancer was found earlier, even if she dies at the same age she would have without screening.

“You live longer with the knowledge that you have a diagnosis, but you don’t live longer.”

@delbigtree

"This one blew me away."

Texas Attorney General @KenPaxton reached a settlement with Sprouts over its use of Produce Max, an EPA-registered antimicrobial pesticide containing hypochlorous acid, in produce misting systems.

Under the settlement, Sprouts agreed to stop spraying Produce Max on all produce nationwide and to stop using synthetic antimicrobial pesticides on organic produce.

Most shoppers probably never imagined the produce misters could be spraying a pesticide at all.

“This is a win-win for everybody, including really the consumer.

@delbigtree

Dr. Shannon Kroner says she would like to see more movement on vaccines, including the mRNA shots, but believes Robert F. Kennedy Jr. is facing an enormous fight inside the system.

“I’ve been in this fight for so long, so to see where we are today... that is a blessing.”

Her new children’s book, Making America Healthy Again, takes that larger conversation and brings it to families in a way both kids and parents can understand.

@delbigtree

A vaccine only gets liability protection under the 1986 Act once ACIP votes to recommend it and the CDC puts it on the schedule. That’s the exact moment the shield activates.

Move a vaccine off the recommended schedule and into shared decision-making instead, and it starts losing that protection. There are more steps after that before it’s fully gone, and whether Bobby completes all of them is still an open question. But watching him take that first step is watching him line up a path to undo the 1986 Act.

@delbigtree

MAHA is not one issue, and not everyone inside the movement feels the same way about its progress.

Some are seeing major movement on food and regenerative farming. Others are furious that mRNA vaccines remain on the market. Parents who have spent decades fighting for recognition of vaccine injury are finally hearing those words spoken by the government.

Del Bigtree’s message as those tensions grow: stop turning on each other.

“Let’s recognize that we’re all in this together. We’re all needed.”

Then take that energy somewhere it can actually matter: tell your representatives what you want changed.

@delbigtree

Years ago, Dr. Shannon Kroner invited ZDoggMD to join a public vaccine debate.

He responded by mocking her credentials and the invitation on his show.

Now that ZDogg is publicly questioning some of his earlier views on vaccines, Kroner says she is not looking for a rematch.

“What I would like is an apology.”

The broader debate she wanted back then still has not happened.

@delbigtree

If you have old gray fillings, Dr. Marc DiNola says they are likely mercury amalgam.

He explains that mercury can be recirculated through the body, making proper removal especially important.

For people wondering where to start, the first step may be as basic as opening your mouth and looking at what is actually there.

@delbigtree

HHS is opening a new vaccine injury clinic focused on studying who may be vulnerable to vaccine injuries and how to prevent them.

Secretary @RobertFKennedyJr. says families who have spent years feeling ignored will now be heard, investigated, and taken seriously.

“For many years, moms and children with vaccine injuries have been marginalized, vilified, demonized, and gaslighted.”

For parents who have been asking the government for recognition for decades, this is a major moment.

@delbigtree

While critics ask why @RobertFKennedyJr. is not moving faster, a federal court fight has already disrupted ACIP meetings and challenged his ability to reshape the vaccine advisory panel.

The Justice Department is now appealing that ruling, with an appellate judge questioning the legal basis for blocking Kennedy’s appointees.

Two ACIP meetings have already been cancelled during the litigation. Another is scheduled for next week.

This is the fight happening behind the scenes over who gets to shape vaccine policy at HHS

@DelBigtree

Big Pharma Buys Your Doctor With Dinner

A federal judge in Massachusetts blocked RFK Jr.’s ACIP appointees. The DOJ is now fighting in the First Circuit Court of Appeals to restore them. Del breaks down what the court actually said, why the judge’s reasoning fell apart, and what a new Cochrane Collaboration meta-analysis says about why conflicts of interest on that committee are exactly the problem Kennedy was trying to fix.

Chief U.S. Circuit Judge David Barron said from the bench that the lower court’s order lacked any explanation for why blocking Kennedy’s 13 appointees was legally authorized or justified. He said it was “hard to know precisely what harm this relief was designed to address.” All Kennedy did was reconstitute ACIP with members who have no pharmaceutical financial ties.

A meta-analysis of 93 studies by the Cochrane Collaboration now confirms what ACIP’s critics have argued for years: pharmaceutical industry contact is associated with less appropriate prescribing, greater prescription volume, and higher costs. The study’s author, Dr. Lisa Barrow, put it plainly. More contact with drug company promotion means prescribing becomes less appropriate, more frequent, and more expensive. That finding came from meals alone. ACIP members receive millions from vaccine manufacturers and vote on recommendations for the entire country.

Del notes that Kennedy’s original target was the hepatitis B birth dose, a vaccine unnecessary for newborns not born to hepatitis B-positive mothers. That single proposed change triggered the injunction, blocked every ACIP meeting, and stripped Kennedy of the advisory infrastructure needed to act on anything else.

@delbigtree

A patient tells their doctor, my arm started losing feeling two days after the vaccine, and now I’m losing feeling in my chest and I’m having trouble breathing. The doctor’s answer is that it couldn’t be the vaccine.

That’s the argument happening in exam rooms right now instead of the one that should be happening. Nobody is asking which vaccine, or when, or what we should be doing to help this person’s body recover. No doctor anywhere is working on how to stop a vaccine injury once it starts, how to keep something like transverse myelitis from spreading through the whole body and paralyzing someone.

There should be an entire field of science dedicated to treating adverse reactions as they unfold. Instead our doctors and scientists have spent decades looking away, and an entire group of people has been injured and had their lives destroyed in the dark. That’s not fair. It’s not right. It is not humane.

@delbigtree

Del Bigtree says @RobertFKennedyJr. missed badly this week when he blamed falling measles vaccination rates on COVID-era shutdowns.

For Del, the deeper break happened when people watched the public health system lose credibility during COVID and stopped trusting what they were being told.

“If you’re there to bring transparency to science, please stay focused on that duty.”

Accountability matters most when it applies to your own side.

@delbigtree

Peter Navarro says one of his biggest regrets from COVID was watching 65 million hydroxychloroquine tablets sit unused after federal agencies turned against the drug.

He points to Fauci’s earlier support, long-standing use of hydroxychloroquine for other conditions, and prior NIH research on chloroquine against SARS coronaviruses.

Then the conversation goes somewhere even bigger: what federal health officials were already saying in 2019 about rapidly deploying new vaccine technology during a future outbreak.

Looking back now, those old clips hit very differently.

@delbigtree