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Castle Biosciences, Inc. (Nasdaq: CSTL), a skin cancer diagnostics company providing personalized genomic information to improve cancer treatment decisions, today announced that its data were featured in two oral presentations during the 2020 American Society for Dermatologic Surgery (ASDS) Virtual Annual Meeting, Oct. 9-11, 2020.DecisionDx ® -Melanoma: Skin Cancer and Reconstruction Session; Friday, October 9, 2020"Cutaneous Melanoma Prognostic Model Combining 31-gene Expression Profile and Sentinel Lymph Node Biopsy" was presented by Aaron Farberg, M.D., Baylor University Medical Center, Dallas, Texas.DecisionDx-Melanoma is a gene expression profile test that uses an individual patient's tumor biology to predict individual risk of cutaneous melanoma metastasis or recurrence, as well as sentinel lymph node positivity, independent of traditional staging factors."As most sentinel lymph node biopsies are negative, there is a need to identify which melanoma patients can forgo sentinel lymph node biopsy (SNLB)," said Dr. Farberg. "Based on the cohort described in a recent meta-analysis by Greenhaw and colleagues, we modeled the use of Castle's DecisionDx-Melanoma test to determine whether it might alter the predictive value of SLNB alone in high-risk patients, and whether the test might identify patients who would not benefit from SLNB. In fact, we found that use of the test stratifies risk in the cohort studied, which can help focus the resources needed for SLNB on patients with genuinely higher risk, thereby reducing surgical risks for patients who can avoid SLNB."Study methods and findings:The study objective was to model the use of DecisionDx-Melanoma to triage cutaneous melanoma patients for SLNB, to evaluate the outcomes of low-risk patients who can forgo SLNB and to evaluate the combined accuracy of DecisionDx-Melanoma and SLNB in high-risk patients.The model was based on use of DecisionDx-Melanoma to triage the patients from the recently published systematic review and meta-analysis (Greenhaw et al. JAAD, Sept., 2020), assuming that:Patients with a Class 1A result who were 55 years of age or older with T1-T2 melanoma would not undergo SLNB;The negative predictive value of DecisionDx-Melanoma for recurrence-free survival, distant metastasis free survival and ultimately melanoma specific survival would be high for patients who would not have undergone SLNB due to DecisionDx-Melanoma triage; andThe remaining patients would undergo SLNB.Result showed that:69% of all patients could forgo an SLNB due to a DecisionDx-Melanoma Class 1A test result, and the negative predictive value for 5-year melanoma specific survival was 98%.For the remaining 31% of patients who would undergo an SLNB:Sensitivity for melanoma specific death was 87% for DecisionDx-Melanoma compared with 73% for SLNB. Combining DecisionDx-Melanoma with SLNB improved sensitivity to 96%.Negative predictive value for melanoma specific death was 95% for DecisionDx-Melanoma, compared with 94% for SLNB. Combining DecisionDx-Melanoma with SLNB improved negative predictive value to 98%.The study concluded that use of DecisionDx-Melanoma to triage patients with a Class 1A result, who were at least 55 years old with T1-T2 melanoma, could have reduced SLNB procedures in that population by 69%. Use of DecisionDx-Melanoma for SLNB triage can focus the SLNB procedure on patient populations at higher risk for a positive sentinel lymph node, thereby reducing surgical risks and better utilizing healthcare resources.DecisionDx ® -SCC: Skin Cancer and Reconstruction Session; Friday, October 9, 2020"Clinical Validation and Incorporation of a Prognostic 40-gene Expression Profile Test into Clinicopathological Risk Assessment for Cutaneous Squamous Cell Carcinoma (cSCC)" was presented by Sherrif Ibrahim, M.D., Ph.D., associate professor, University of Rochester Medical Center.DecisionDx-SCC is Castle's prognostic…

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<strong>tornare a fare/dire qualcosa</strong> do/say something again<strong>ben tornato!</strong> welcome back!* * *<strong>1</strong> to return; ( andare di nuovo) to go* back; ( venire di nuovo) to come* back: quando tornerai in America?, when will you go back to America?; tornerò sicuramente a fare una vacanza in Spagna, I'll definitely go back to Spain for a holiday; tornare in città, to go back to town; tornò al proprio posto, he went back to his seat; tornare a vivere a Londra, to go back to live in London; ''A che ora torni?'' ''Tornerò per le otto'', ''What time are you coming back?'' ''I'll be back for eight''; tornare a casa, to return (o to go o to come) home; torna sempre a casa tardi, he always comes home late; datemi retta, torniamo indietro, admit I'm right, let's turn back; torna presto!, come back soon!; torna indietro!, come back!; tornare in treno, to come back, to go back by train; tornare in aereo, to come back, to go back by plane (o to fly back); tornava dal lavoro, da scuola, he was coming back from work, from school; quando tornò al lavoro dopo le ferie..., when he went back to work after the holidays...; tornò dai suoi genitori, he went back to his parents; basta, torno da mia madre!, that's it, I'm going back to my mother's!; fare segno a qlcu. di tornare, to wave (o to beckon) s.o. back // mi è tornato alla, in mente, I've remembered; tornare con la mente a qlco., to remember (o to recall) sthg.; il suo nome non mi torna alla mente, I don't remember (o recall) his name; far tornare qlco. alla mente di qlcu., to make s.o. remember sthg. // tornare al punto di partenza, to come full circle (o to come back to where one started); tornare in tutta fretta, to hasten back; tornare sano e salvo, to return safe and sound; tornare sui propri passi, to turn back (o to retrace one's steps) // è tornata l'estate, summer is here (o back again) // ho promesso di aiutarlo e non tornerò indietro, I have promised to help him and I won't go back on it // tornare sulle proprie decisioni, to change one's mind (o to go back on a decision) // mi ritornano le forze, I am recovering my strength // il passato non torna, time that is passed will never come again // si torna alle gonne corte, we are going back to short skirts // torniamo a noi, a bomba, let's get back to the subject // tornare a galla, (<em class="c5">fig.) to come up again // tornare in gola, ( di cibi) to repeat // tornare alla carica, (<em class="c5">fig.) to make a fresh attempt // tornare in vita, (<em class="c5">fig.) to come back to life // tornare in sé, to regain consciousness (o to come round), (<em class="c5">fig.) to become oneself again (o to be one's old self again) // tornare sul passato, to go back (o to revert) to the past // tornare in possesso, to recover sthg., (<em class="c5">dir.) to regain possession<strong>4</strong> ( quadrare) to balance, to square, to be correct: il conto torna, the account is correct, (<em class="c5">fig.) it squares; i conti non tornano, the accounts don't balance, (<em class="c5">fig.) it doesn't square; fare tornare i conti, to equalize accounts; vedrai che il conto torna, (<em class="c5">fig.) you'll see that things will work out // il tuo discorso non torna, your speech doesn't make sense; c'è qualcosa che non mi torna nelle sue parole, there's something not quite right (o that doesn't add up) in her words; ti torna?, have you got it?* * *[tor'nare]1) to return, go (o come) back<strong>è tornato alla carica con la sua idea di... — he's gone back to the old idea of</strong>...<strong>è tornato a dire/a fare... — he's back to saying/doing</strong>...<strong>tornare in sé — to regain consciousness, come to one's senses, come round, to be back to one's old self</strong>2) to become again3) to be right, be correct4) ) to turn out (to be), prove (to be)<strong>2</strong>. vt* * *[tor'nare]<strong>tornare in auto, aereo — to drive, fly back</strong><strong>tornare col pensiero a qcs. — to cast one's mind back over st…

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