Could @ TheRealCShinkle save the Upper East Side, Upper West Side and Midtown? Here she explains what’s at stake when people put Qatar’s or Syria’s agendas ahead of New York and New Yorkers.

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"Voters are hungry for common-sense, values-driven candidates."

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"Could a new bill help you keep more of your paycheck?"

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"Common Sense vs. Socialism: The Fight to Save New York"

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"Is the DSA Funded by the CCP?"

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The Upper East and West Sides of Manhattan, plus the economic heartbeat of America, Midtown, really need to consider what life, finances and security will be like represented by a Mamdani-endorsing DSA supplicant, Micah Lasher. Will anyone be truly safe, let alone economically secure? Caroline Shinkle is a common sense R challenging Lasher, who can keep her constituents safe, and secure their economic wellbeing; she is a uniter in a time of horrid division. Maybe a deep blue district can get past the labels D and R to vote for its own safety and wellbeing.

https://yucommentator.org/2026/09/interview-with-caroline-shinkle-candidate-for-u-s-congress/

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These women in a ‘modest fashion’ show in a CHURCH look really happy.

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So open the Rafah crossing. Let Egypt allow all in those materials. Why aren’t they? I’ve been asking this questions for weeks with no answer. It’s absurd post- Oct 7 to ask Israel to open its Southern border.

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Meet me there, Sept 30. Let’s save New York from Marxists and jihadists and their craven, dangerous friends.

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Egypt could have let in every Gazan refugee from bombardment. It could let into Gaza every truck with aid and medicines. It could allow Gazans to travel freely to the rest of the world. Why won’t they?

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Every woman has actual nightmares that look like this.

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It was such a wonderful country.

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@ NYCMayor and his NGO nepo baby cronies will be better landlords and builders than the private sector. A massive portion of the exterior cladding of an ‘affordable housing’ condo in NY, blew off in the wind over the weekend, smashed a car next door and made the next door townhouse uninhabitable. It seems to have been glued on.

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Thank heaven for this administration.

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Canadian Institute press release at this late date promotes Remdesevir to treat COVID. What could go wrong?
‘Media Release: Unique structure of COVID protein suggests new target for drugs
Read the story online | Watch a video about this research
A protein vital to the replication of the virus that causes COVID-19, known as the main protease, or Mpro, makes a good target for antiviral drugs like remdesivir. Now researchers using the Canadian Light Source at the University of Saskatchewan have uncovered a potential new way for drugs to disrupt that protein to treat the disease.
“Mpro is a good target for drugs. If we can halt its activity, we can halt viral replication,” says Todd Holyoak, a structural biologist at the University of Waterloo.
The SARS-CoV-2 virus replicates itself in an unusual way, he says. The proteins encoded in its RNA genome get translated into one long protein called a polyprotein, which is then chopped up into its constituent parts. Mpro is the protein that does most of that chopping.
Mpro is itself a little unusual. It only functions when there are two copies of the protein stuck together (called a dimer). And it contains more of an amino acid called cysteine than most proteins. This is significant because cysteine is highly susceptible to damage from oxidation, which is a key way the body can combat infection. This should be a liability for a viral protein. Yet SARS-CoV-2 is obviously a very effective virus.
“That’s kind of a conundrum,” says Holyoak.
Earlier research by Holyoak and his colleagues found that, under oxidative conditions, Mpro protects its vulnerable cysteines by temporarily linking C117 and C145. When conditions improve, the bond breaks.
“We wanted to understand, what would the effect be of over-oxidizing one of those two cysteines? Would there be other consequences from a structural point of view?” he says.
The researchers created altered versions of the protein that had one of the cysteines replaced with aspartate, another amino acid that closely resembles the oxidized form of cysteine. They discovered that when C117 was disabled, the Mpro dimer split into two separate proteins called monomers. The team's findings are published in the journal Protein Science.
Using the CLS, they were – possibly for the time ever -- able to see the 3D structure of the Mpro monomer and found it had a very different shape than when it was part of a dimer. That, says Holyoak, could open up new ways to fight COVID-19.
Remdesivir, and other drugs in development, go after the dimer’s active site to block it from binding to and cutting up the polyprotein. It’s an effective mechanism, but the virus may eventually be able to develop a resistance to it. Instead, Holyoak envisions drugs that target the monomer version of the protein and stop it from forming the active dimer.
“If we can find molecules that can bind and stabilize the monomer form, it will never even form the dimer,” says Holyoak. “That opens up a whole new therapeutic avenue.”
-30-
More CLS science highlights
The Canadian Light Source (CLS) is a national research facility of the University of Saskatchewan, and Canada’s only synchrotron. Each year, more than 1,000 Canadian and international researchers from universities, government, and industry use the CLS's ultrabright light to address challenges in health, agriculture, energy, the environment, and advanced materials, supported by a team of 260 CLS employees. By enabling discoveries, training the next generation of scientists, and helping Canadian companies innovate, the CLS contributes to Canada's scientific excellence, economic competitiveness, and prosperity.
The Canada Foundation for Innovation, the Government of Saskatchewan, and the University of Saskatchewan fund CLS operations.
Access images and B-roll related to this research
To arrange an interview with the researcher, contact:
Greg Basky
Communications Coordinator
Canadian Light Source
306-370-9446
greg.basky@lightsource.ca’

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Birmingham city council has moved to ban the English and British flags.
They have done this in the “interest of public safety.”
They propose instead to hoist the Pakistani flag.
Banning our own flag in our own country? Whoever proposed this should be deported at once.
This is how to lose your country in only two decades without a single shot fired.


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