Forwarded from Little Durhamred
Calling all health professionals, health, public services & ex-armed forces who are planning to attend the london protest on the 24th April; there will be a group of us marching together in our uniforms.
Hoping that this will send a message that some of us are pushing back on the agenda & prepared to be counted, to make them question the mass coerced vaccination programme (& all that surrounds it)
And I’m hope it may encourage other workers to step up & speak out.
Please join if you are coming and would like to walk with us 🙏
Please if you join say hello & state what your job role is (or was) x
https://t.me/ukHWprotest
Hoping that this will send a message that some of us are pushing back on the agenda & prepared to be counted, to make them question the mass coerced vaccination programme (& all that surrounds it)
And I’m hope it may encourage other workers to step up & speak out.
Please join if you are coming and would like to walk with us 🙏
Please if you join say hello & state what your job role is (or was) x
https://t.me/ukHWprotest
ANTIBODY DEPENDENT ENHANCEMENT (ADE) OR VACCINE ANTIBODY DEPENDENT ENHANCEMENT (VADE):
"Lessons from SARS and MERS vaccines
The genomes of SARS-CoV-2 and SARS-CoV share 79.6% sequence identity70, and they use the same receptor, angiotensin-converting enzyme 2 (ACE2), to enter cells71. Therefore, SARS vaccine-induced immune responses, which have already been studied, would be useful in the evaluation of COVID-19 candidate vaccines. In 2003, soon after isolation of SARS-CoV viral particles and release of the viral genome sequence, SARS vaccine design began. Similarly to COVID-19 vaccine developers, researchers first sought SARS vaccines based on inactivated virus, recombinant subunit proteins and recombinant vectors.
A recombinant modified vaccinia virus Ankara vector expressing SARS-CoV S protein elicited a rapid and vigorous NAb response in ferrets; however, a strong inflammatory response in the liver of immunized ferrets occurred after challenge with SARS-CoV74,75. More studies then demonstrated that SARS vaccines, based on either inactivated virus or a recombinant vector, could induce eosinophils and TH2 cell-skewed immune responses on subsequent challenge with SARS-CoV in a mouse model76,77,78, which is reminiscent of RSV vaccine-induced ERD in infants. Similarly, an inactivated SARS-CoV vaccine and a SARS-CoV S protein-derived peptide vaccine both induced severer lung damage in rhesus macaques after SARS-CoV challenge79. A DNA vaccine encoding the S protein of SARS-CoV induced CD4+ and CD8+ T cell and NAb responses in a mouse model and in a phase I clinical trial80,81.
ADE was also observed in SARS vaccines. A SARS vaccine based on recombinant SARS-CoV S protein protected hamsters from SARS-CoV infection; however, the S protein-specific antibodies could mediate FcR-dependent entry into B cells in vitro82,83. Furthermore, diluted SARS-CoV S protein-specific antibodies resulted in increased virus infectivity and cytopathic effect in an HL-CZ human promonocyte cell line84. Except for the ADE, antibody-mediated unbalanced macrophage activation has been reported to be associated with obvious lung injury in vivo. Passive transfer of anti-S IgG abrogated wound-healing responses and promoted proinflammatory monocyte and macrophage recruitment and accumulation in the lungs of macaques after viral challenge, indicating that SARS-CoV S protein-specific antibodies could elicit pathogenic immune responses, as well as enhance disease severity after SARS-CoV infection24. Notably, the evidence for anti-S IgG-mediated ADE was observed only in vitro. Therefore, ADE seems a less critical issue than other antibody- and TH2 cell-mediated immunopathology in vivo.
MERS-CoV belongs to the genus Betacoronavirus, which also includes SARS-CoV and SARS-CoV-2. Since the virus was first identified in Saudi Arabia in 2012, many vaccine techniques, including subunit vaccines, viral vector and DNA-based vaccines, and inactivated and live attenuated vaccines, have been applied to develop MERS vaccines85. Many of them could induce adequate immune responses and protect vaccinated animals from subsequent MERS-CoV infection86. However, two studies independently reported that mice vaccinated with inactivated MERS-CoV developed TH2 cell-biased immune responses and increased eosinophil infiltrates after viral challenge87,88. Several lines of evidence have demonstrated that MERS S protein-specific antibodies are able to mediate ADE. A monoclonal antibody induced by recombinant MERS-CoV S1 bound to cell surface IgG FcR and mediated viral entry into HEK293T cells exogenously expressing FcRs and macrophages (induced from THP-1 monocytes) endogenously expressing FcRs through canonical viral receptor-dependent pathways89. Rabbits infected with MERS-CoV developed MERS-CoV S protein-specific antibodies without neutralizing activity and protection of animals against reinfection, and concerningly, MERS-CoV-reinfected rabbits showed enhanced pulmonary inflammation associated with complement activation90.
"Lessons from SARS and MERS vaccines
The genomes of SARS-CoV-2 and SARS-CoV share 79.6% sequence identity70, and they use the same receptor, angiotensin-converting enzyme 2 (ACE2), to enter cells71. Therefore, SARS vaccine-induced immune responses, which have already been studied, would be useful in the evaluation of COVID-19 candidate vaccines. In 2003, soon after isolation of SARS-CoV viral particles and release of the viral genome sequence, SARS vaccine design began. Similarly to COVID-19 vaccine developers, researchers first sought SARS vaccines based on inactivated virus, recombinant subunit proteins and recombinant vectors.
A recombinant modified vaccinia virus Ankara vector expressing SARS-CoV S protein elicited a rapid and vigorous NAb response in ferrets; however, a strong inflammatory response in the liver of immunized ferrets occurred after challenge with SARS-CoV74,75. More studies then demonstrated that SARS vaccines, based on either inactivated virus or a recombinant vector, could induce eosinophils and TH2 cell-skewed immune responses on subsequent challenge with SARS-CoV in a mouse model76,77,78, which is reminiscent of RSV vaccine-induced ERD in infants. Similarly, an inactivated SARS-CoV vaccine and a SARS-CoV S protein-derived peptide vaccine both induced severer lung damage in rhesus macaques after SARS-CoV challenge79. A DNA vaccine encoding the S protein of SARS-CoV induced CD4+ and CD8+ T cell and NAb responses in a mouse model and in a phase I clinical trial80,81.
ADE was also observed in SARS vaccines. A SARS vaccine based on recombinant SARS-CoV S protein protected hamsters from SARS-CoV infection; however, the S protein-specific antibodies could mediate FcR-dependent entry into B cells in vitro82,83. Furthermore, diluted SARS-CoV S protein-specific antibodies resulted in increased virus infectivity and cytopathic effect in an HL-CZ human promonocyte cell line84. Except for the ADE, antibody-mediated unbalanced macrophage activation has been reported to be associated with obvious lung injury in vivo. Passive transfer of anti-S IgG abrogated wound-healing responses and promoted proinflammatory monocyte and macrophage recruitment and accumulation in the lungs of macaques after viral challenge, indicating that SARS-CoV S protein-specific antibodies could elicit pathogenic immune responses, as well as enhance disease severity after SARS-CoV infection24. Notably, the evidence for anti-S IgG-mediated ADE was observed only in vitro. Therefore, ADE seems a less critical issue than other antibody- and TH2 cell-mediated immunopathology in vivo.
MERS-CoV belongs to the genus Betacoronavirus, which also includes SARS-CoV and SARS-CoV-2. Since the virus was first identified in Saudi Arabia in 2012, many vaccine techniques, including subunit vaccines, viral vector and DNA-based vaccines, and inactivated and live attenuated vaccines, have been applied to develop MERS vaccines85. Many of them could induce adequate immune responses and protect vaccinated animals from subsequent MERS-CoV infection86. However, two studies independently reported that mice vaccinated with inactivated MERS-CoV developed TH2 cell-biased immune responses and increased eosinophil infiltrates after viral challenge87,88. Several lines of evidence have demonstrated that MERS S protein-specific antibodies are able to mediate ADE. A monoclonal antibody induced by recombinant MERS-CoV S1 bound to cell surface IgG FcR and mediated viral entry into HEK293T cells exogenously expressing FcRs and macrophages (induced from THP-1 monocytes) endogenously expressing FcRs through canonical viral receptor-dependent pathways89. Rabbits infected with MERS-CoV developed MERS-CoV S protein-specific antibodies without neutralizing activity and protection of animals against reinfection, and concerningly, MERS-CoV-reinfected rabbits showed enhanced pulmonary inflammation associated with complement activation90.
Overall, signs of VADE are less prominent for MERS vaccines than for SARS vaccines. Currently, one DNA MERS vaccine (INO-4700) and two viral-vectored MERS S protein-based vaccines have shown a favourable safety profile and induced humoral and cellular immune responses against MERS-CoV in phase I clinical trials"
https://www.nature.com/articles/s41579-020-00462-y#Sec11
https://www.nature.com/articles/s41579-020-00462-y#Sec11
Nature
Learning from the past: development of safe and effective COVID-19 vaccines
Nature Reviews Microbiology - In this Perspective, Su, Du and Jiang discuss lessons from previous vaccine development efforts for other viruses and how the mechanisms of vaccine-associated disease...
"#4: THE "DATA GAPS" SUBMITTED TO THE FDA BY THE VACCINE MAKERS
When vaccine makers submitted their papers to the FDA for the Emergency Use Authorization (Note: An EUA is not the same as a full FDA approval), among the many "Data Gaps" they reported was that they have nothing in their trials to suggest they overcame that pesky problem of Vaccine Enhanced Disease.
They simply don't know--i.e. they have no idea if the vaccines they've made will also produce the same cytokine storm (and deaths) as previous attempts at such products.
As Joseph Mercola points out...
"Previous attempts to develop an mRNA-based drug using lipid nanoparticles failed and had to be abandoned because when the dose was too low, the drug had no effect, and when dosed too high, the drug became too toxic. An obvious question is: What has changed that now makes this technology safe enough for mass use?"
If that's not alarming enough, here are other gaps in the data--i.e. there is no data to suggest safety or efficacy regarding:
Anyone younger than age 18 or older than age 55
Pregnant or lactating mothers
Auto-immune conditions
Immunocompromised individuals
No data on transmission of covid
No data on preventing mortality from covid
No data on duration of protection from covid
Hard to believe right?
In case you think I'm making this up, or want to see the actual documents sent to the FDA by Pfizer and Moderna for their Emergency Use Authorization, you can check out this, or this respectively. The data gaps can be found starting with page 46 and 48 respectively.
For now let's turn our eyes to the raw data the vaccine makers used to submit for emergency use authorization.
#5: NO ACCESS TO THE RAW DATA FROM THE TRIALS
Would you like to see the raw data that produced the "90% and 95% effective" claims touted in the news?
Me too...
But they won't let us see that data.
As pointed out in the BMJ, something about the Pfizer and Moderna efficacy claims smells really funny.
There were “3,410 total cases of suspected, but unconfirmed covid-19 in the overall study population, 1,594 occurred in the vaccine group vs. 1,816 in the placebo group.”
Wait...what?
Did they fail to do science in their scientific study by not verifying a major variable?
Could they not test those "suspected but unconfirmed" cases to find out if they had covid?
Apparently not.
Why not test all 3,410 participants for the sake of accuracy?"
https://www.deconstructingconventional.com/post/18-reason-i-won-t-be-getting-a-covid-vaccine
When vaccine makers submitted their papers to the FDA for the Emergency Use Authorization (Note: An EUA is not the same as a full FDA approval), among the many "Data Gaps" they reported was that they have nothing in their trials to suggest they overcame that pesky problem of Vaccine Enhanced Disease.
They simply don't know--i.e. they have no idea if the vaccines they've made will also produce the same cytokine storm (and deaths) as previous attempts at such products.
As Joseph Mercola points out...
"Previous attempts to develop an mRNA-based drug using lipid nanoparticles failed and had to be abandoned because when the dose was too low, the drug had no effect, and when dosed too high, the drug became too toxic. An obvious question is: What has changed that now makes this technology safe enough for mass use?"
If that's not alarming enough, here are other gaps in the data--i.e. there is no data to suggest safety or efficacy regarding:
Anyone younger than age 18 or older than age 55
Pregnant or lactating mothers
Auto-immune conditions
Immunocompromised individuals
No data on transmission of covid
No data on preventing mortality from covid
No data on duration of protection from covid
Hard to believe right?
In case you think I'm making this up, or want to see the actual documents sent to the FDA by Pfizer and Moderna for their Emergency Use Authorization, you can check out this, or this respectively. The data gaps can be found starting with page 46 and 48 respectively.
For now let's turn our eyes to the raw data the vaccine makers used to submit for emergency use authorization.
#5: NO ACCESS TO THE RAW DATA FROM THE TRIALS
Would you like to see the raw data that produced the "90% and 95% effective" claims touted in the news?
Me too...
But they won't let us see that data.
As pointed out in the BMJ, something about the Pfizer and Moderna efficacy claims smells really funny.
There were “3,410 total cases of suspected, but unconfirmed covid-19 in the overall study population, 1,594 occurred in the vaccine group vs. 1,816 in the placebo group.”
Wait...what?
Did they fail to do science in their scientific study by not verifying a major variable?
Could they not test those "suspected but unconfirmed" cases to find out if they had covid?
Apparently not.
Why not test all 3,410 participants for the sake of accuracy?"
https://www.deconstructingconventional.com/post/18-reason-i-won-t-be-getting-a-covid-vaccine
Deconstructing Con.
18 Reasons I Won't Be Getting a Covid Vaccine
A few friends have asked my thoughts on the covid jab(s) so I thought it was time to write an article on the topic.All my friends had not heard most of the details I shared, so I figured you might appreciate hearing some of what I told them.Knowing how contentious…
A message to the public from Dr Tess Lawrie
Dr Lawrie appeals to the public to inform themselves on the evidence of the efficacy of ivermectin and share it ...
Dr Theresa Lawrie
Evidence-Based Medicine Consultancy Ltd Bath, United Kingdom
+44 7826 939464
e-bmc.co.uk
Vimeo https://vimeo.com/533986005/0d843fedf8
You can now find the urgent message to the public from Dr. Tess Lawrie with Italian, Spanish and French subtitles on #vimeo #ivermectin
Italian - https://t.co/yyM9ZRQjWr
Spanish - https://t.co/1uybQyMzu5
French - https://t.co/nuMvTLJ8xN
Dr Lawrie appeals to the public to inform themselves on the evidence of the efficacy of ivermectin and share it ...
Dr Theresa Lawrie
Evidence-Based Medicine Consultancy Ltd Bath, United Kingdom
+44 7826 939464
e-bmc.co.uk
Vimeo https://vimeo.com/533986005/0d843fedf8
You can now find the urgent message to the public from Dr. Tess Lawrie with Italian, Spanish and French subtitles on #vimeo #ivermectin
Italian - https://t.co/yyM9ZRQjWr
Spanish - https://t.co/1uybQyMzu5
French - https://t.co/nuMvTLJ8xN
Already Had A COVID-19 Infection Or Think You Did? Don’t Rush To Get The Vaccine — It May Not Be Safe For You. | by Hooman Noorchashm | Feb, 2021 | Medium
"Once a person is naturally infected by a virus (any virus), antigens from that virus persist in the body for very long after viral replication has stopped and clinical signs of infection have resolved. So, when a vaccine reactivates an immune response in such recently infected persons, the tissues harboring the persisting viral antigen are targeted, inflamed and damaged by the immune response.
In the case of SARS-CoV-2, we know that the virus naturally infects the heart, the inner lining of blood vessels, the lungs and the brain. So, these are likely to be some of the critical organs that will contain persistent viral antigens in the recently infected — AND, following reactivation of the immune system by a vaccine, these tissues can be expected to be targeted and damaged.
If young and otherwise healthy persons, recently infected, could tolerate such an adverse side-effects of the vaccine, it is highly likely that many of the elderly and frail, or those with serious cardiovascular risk factors, would not.
So, I feel obliged to suggest, as a physician and immunologist, that any persons with “known or suspected” COVID-19 infections avoid or delay getting the COVID-19 vaccine.
Certainly, any elderly and frail persons and those with cardiovascular — or any person who suspects having been exposed to COVID-19 — should be screened for the virus and for COVID-19 IgG antibodies. If either of these screening tests are positive, these persons ought to delay or avoid being vaccinated.
Indiscriminate deployment of a vaccine treatment in the midst of an outbreak is highly likely to be a clinical and scientific error — and the United States public health agencies are allowing this error to occur, unmitigated.
Therefore, it is necessary for all responsible citizens and professionals to carefully consider whether naturally infected persons should get vaccinated indiscriminately."
https://noorchashm.medium.com/already-or-had-a-covid-19-infection-or-think-you-did-b282f9471605
"Once a person is naturally infected by a virus (any virus), antigens from that virus persist in the body for very long after viral replication has stopped and clinical signs of infection have resolved. So, when a vaccine reactivates an immune response in such recently infected persons, the tissues harboring the persisting viral antigen are targeted, inflamed and damaged by the immune response.
In the case of SARS-CoV-2, we know that the virus naturally infects the heart, the inner lining of blood vessels, the lungs and the brain. So, these are likely to be some of the critical organs that will contain persistent viral antigens in the recently infected — AND, following reactivation of the immune system by a vaccine, these tissues can be expected to be targeted and damaged.
If young and otherwise healthy persons, recently infected, could tolerate such an adverse side-effects of the vaccine, it is highly likely that many of the elderly and frail, or those with serious cardiovascular risk factors, would not.
So, I feel obliged to suggest, as a physician and immunologist, that any persons with “known or suspected” COVID-19 infections avoid or delay getting the COVID-19 vaccine.
Certainly, any elderly and frail persons and those with cardiovascular — or any person who suspects having been exposed to COVID-19 — should be screened for the virus and for COVID-19 IgG antibodies. If either of these screening tests are positive, these persons ought to delay or avoid being vaccinated.
Indiscriminate deployment of a vaccine treatment in the midst of an outbreak is highly likely to be a clinical and scientific error — and the United States public health agencies are allowing this error to occur, unmitigated.
Therefore, it is necessary for all responsible citizens and professionals to carefully consider whether naturally infected persons should get vaccinated indiscriminately."
https://noorchashm.medium.com/already-or-had-a-covid-19-infection-or-think-you-did-b282f9471605
Open Letter from Christian Leaders to the Prime Minister Concerning Vaccine Passport Proposals
Christian Leaders — Vaccine Passport Letter
https://vaccinepassportletter.wordpress.com/
Christian Leaders — Vaccine Passport Letter
https://vaccinepassportletter.wordpress.com/
Christian Leaders — Vaccine Passport Letter
Visit the post for more.
Forwarded from Mike Yeadon
In response to news that “government may ask the under 30s to have a different vaccine than AZ”.
The other vaccines are dangerous too.
Not in everyone.
But none are close to safe enough to use as a public health prophylactic.
Vaccinating everyone will result in some young (& older) people DYING because they were vaccinated. These people were never at risk of death from covid19.
Ask yourself what kind of public health policy kills some citizens, unavoidably, in order to get everyone vaccinated?
Think! It’s so everyone can be bagged & tagged on a global ID system.
The perfect tool of totalitarian thug castes
Ask yourself why they want that total control. And what they might do with that power.
Yes, you’ve got it now.
So....do NOT permit a vaccines passports system to go live.
That marks the irreversibly ending of liberal democracy. I kid you not.
Just don’t say you weren’t warned, because you were. Repeatedly.
Dr Mike Yeadon
The other vaccines are dangerous too.
Not in everyone.
But none are close to safe enough to use as a public health prophylactic.
Vaccinating everyone will result in some young (& older) people DYING because they were vaccinated. These people were never at risk of death from covid19.
Ask yourself what kind of public health policy kills some citizens, unavoidably, in order to get everyone vaccinated?
Think! It’s so everyone can be bagged & tagged on a global ID system.
The perfect tool of totalitarian thug castes
Ask yourself why they want that total control. And what they might do with that power.
Yes, you’ve got it now.
So....do NOT permit a vaccines passports system to go live.
That marks the irreversibly ending of liberal democracy. I kid you not.
Just don’t say you weren’t warned, because you were. Repeatedly.
Dr Mike Yeadon
Prince Philip received the first Covid19 injection on the 9th January 2021. I can't find any confirmation of the date of the second injection. It would have been minimum 4 weeks later or around mid February. He was admitted to hospital on the 17th February 2021. That is possibly just after the second dose of presumably the Astrazeneca Oxford injection.
Forwarded from Oskar
Based on this "The BIRD Recommendation on the Use of Ivermectin for Covid-19":
https://www.francesoir.fr/sites/francesoir/files/media-icons/bird-proceedings-02-03-2021-v151.pdf
Ivermectin for human use is given orally. Prevention and treatment protocols can be derived from the clinical trials and numerous protocols already developed by expert physicians in the field. Suggested protocols include:
- For covid-19 prevention among frontline workers: 12mg every 4 to 6 weeks. (Alam/India protocol)
- For covid-19 prevention among case contacts: 12mg on day 1 and day 3 or 4 post-exposure. (MATH+ and Shouman protocols)
- For covid-19 prophylaxis among elderly nursing home residents: 12mg on day 1 and day 8 after identification of an index case. (Chesler protocol)
- For covid-19 treatment of asymptomatic and mild covid-19 (early outpatient treatment): 0.2mg/kg (~12mg tablet for a 60kg person) on day 1 and day 2. Days 3 to 5 the same, if not recovered. (MATH+ protocol) Some protocols use 0.4mg/kg instead of 0.2mg/kg.
https://www.francesoir.fr/sites/francesoir/files/media-icons/bird-proceedings-02-03-2021-v151.pdf
Ivermectin for human use is given orally. Prevention and treatment protocols can be derived from the clinical trials and numerous protocols already developed by expert physicians in the field. Suggested protocols include:
- For covid-19 prevention among frontline workers: 12mg every 4 to 6 weeks. (Alam/India protocol)
- For covid-19 prevention among case contacts: 12mg on day 1 and day 3 or 4 post-exposure. (MATH+ and Shouman protocols)
- For covid-19 prophylaxis among elderly nursing home residents: 12mg on day 1 and day 8 after identification of an index case. (Chesler protocol)
- For covid-19 treatment of asymptomatic and mild covid-19 (early outpatient treatment): 0.2mg/kg (~12mg tablet for a 60kg person) on day 1 and day 2. Days 3 to 5 the same, if not recovered. (MATH+ protocol) Some protocols use 0.4mg/kg instead of 0.2mg/kg.
👍1
"The Moderna and the Pfizer vaccines encode the full-length spike protein with two mutations for stability. Sinovac's vaccine uses an inactivated virus that presents the wild-type spike protein.
The AstraZeneca ChAdOx1 vaccine uses a chimpanzee adenovirus and encodes the full-length spike protein.
The virus spike protein also has glycans, a type of sugar, coating it, which disguise the virus so that the host immune response does not detect the virus. This is a common strategy used by many viruses to elude the host immune system. So it is crucial that the spike proteins produced by vaccination also produce these glycans to ensure complete mimicking of the virus for the production of suitable neutralizing antibodies.
They found the glycosylation to be a mixture of oligomannose/hybrid and complex-type sites. However, they did not detect O-linked glycans, perhaps because of their low abundance.
https://www.news-medical.net/news/20210409/Oxford-AstraZeneca-COVID-vaccine-induces-cell-spikes-similar-to-SARS-CoV-2s.aspx
The AstraZeneca ChAdOx1 vaccine uses a chimpanzee adenovirus and encodes the full-length spike protein.
The virus spike protein also has glycans, a type of sugar, coating it, which disguise the virus so that the host immune response does not detect the virus. This is a common strategy used by many viruses to elude the host immune system. So it is crucial that the spike proteins produced by vaccination also produce these glycans to ensure complete mimicking of the virus for the production of suitable neutralizing antibodies.
They found the glycosylation to be a mixture of oligomannose/hybrid and complex-type sites. However, they did not detect O-linked glycans, perhaps because of their low abundance.
https://www.news-medical.net/news/20210409/Oxford-AstraZeneca-COVID-vaccine-induces-cell-spikes-similar-to-SARS-CoV-2s.aspx
News-Medical.net
Oxford-AstraZeneca COVID vaccine induces cell spikes similar to SARS-CoV-2's
Scientists from the University of Oxford and the University of Southampton report in the journal ACS Central Science that cells infected with the ChAdOx1 vaccine produce spike proteins on the cells similar to those produced by natural SARS-CoV-2 infection.
SARS-CoV-2 RNA reverse-transcribed and integrated into the human genome | bioRxiv
"In this study, we showed evidence that SARS-CoV-2 RNAs can be reverse-transcribed and integrated into the human genome by several sources of reverse transcriptase such as activated human LINE-1 or co-infected retrovirus (HIV). We found LINE-1 expression can be induced upon SARS-CoV-2 infection or cytokine exposure, suggesting a molecular mechanism responsible for SARS-CoV-2 retro-integration in patients. Moreover, our results suggest that the integrated SARS-CoV-2 sequences can be transcribed, as shown by RNA-Seq and smRNA-FISH data, providing a possible explanation for the presence of viral sequences at later times after initial virus exposure and in the absence of detectable infectious virus1–14. The retro-inserted SRAS-CoV-2 sequences are most likely sub-genomic fragments, as the integration junctions are mostly enriched at the N sequence (Fig. 1d-e), excluding the production of infectious virus. Our data may also explain that patients, after recovery from disease symptoms, may become again positive for viral sequences as detected by PCR1,8–14
https://www.biorxiv.org/content/10.1101/2020.12.12.422516v1.full
"In this study, we showed evidence that SARS-CoV-2 RNAs can be reverse-transcribed and integrated into the human genome by several sources of reverse transcriptase such as activated human LINE-1 or co-infected retrovirus (HIV). We found LINE-1 expression can be induced upon SARS-CoV-2 infection or cytokine exposure, suggesting a molecular mechanism responsible for SARS-CoV-2 retro-integration in patients. Moreover, our results suggest that the integrated SARS-CoV-2 sequences can be transcribed, as shown by RNA-Seq and smRNA-FISH data, providing a possible explanation for the presence of viral sequences at later times after initial virus exposure and in the absence of detectable infectious virus1–14. The retro-inserted SRAS-CoV-2 sequences are most likely sub-genomic fragments, as the integration junctions are mostly enriched at the N sequence (Fig. 1d-e), excluding the production of infectious virus. Our data may also explain that patients, after recovery from disease symptoms, may become again positive for viral sequences as detected by PCR1,8–14
https://www.biorxiv.org/content/10.1101/2020.12.12.422516v1.full
Forwarded from Little Durhamred
Calling all health professionals, health, public services & armed forces who are planning to attend the london protest on the 24th April; there will be a group of us marching together in our uniforms.
Hoping that this will send a message that some of us are pushing back on the agenda & prepared to be counted, to make them question the mass coerced vaccination programme (& all that surrounds it)
And we hope it may encourage other workers to step up & speak out.
Please join if you are coming and would like to walk with us 🙏
Please when you join can you say hi and say what your job role is (or was) x
https://t.me/ukHWprotest
Hoping that this will send a message that some of us are pushing back on the agenda & prepared to be counted, to make them question the mass coerced vaccination programme (& all that surrounds it)
And we hope it may encourage other workers to step up & speak out.
Please join if you are coming and would like to walk with us 🙏
Please when you join can you say hi and say what your job role is (or was) x
https://t.me/ukHWprotest
Native-like SARS-CoV-2 Spike Glycoprotein Expressed by ChAdOx1 nCoV-19/AZD1222 Vaccine | ACS Central Science
"Adenoviruses have broad cell tropism due to the widespread distribution of their cellular receptors such as coxsackie and adenovirus receptor (CAR) and CD46.(37,38) Replication-deficient adenovirus vectored vaccines, such as ChAdOx nCoV-19, are administered intramuscularly and predominantly induce antigen expression in muscle cells, fibroblasts, and professional antigen presenting cells (APCs, including dendritic cells) present in germinal centers of the lymph nodes. These APCs are primed by direct adenovirus infection or by cross-priming from nonimmune cells.(38)
During vaccination, SARS-CoV-2 S protein processing can be dependent on both the receptors present on and the enzymes expressed by the S-producing cells.(39) Presence of the cell entry receptor ACE2 and host-cell proteases including furin and TMPRSS2 can drive conformational rearrangements resulting in postfusion conformations of S. Tissue distribution of ACE2 is primarily in the nasal mucosa and GI tracts, and TMPRSS2 is predominantly expressed in lungs and GI tracts, where cells are susceptible to SARS-CoV-2 infection. In contrast, the muscle, fibroblast, and immune cell types targeted by intramuscularly administered ChAdOx1 nCoV-19 have not been shown to express high levels of ACE2 or TMPRSS2."
https://pubs.acs.org/doi/10.1021/acscentsci.1c00080
"Adenoviruses have broad cell tropism due to the widespread distribution of their cellular receptors such as coxsackie and adenovirus receptor (CAR) and CD46.(37,38) Replication-deficient adenovirus vectored vaccines, such as ChAdOx nCoV-19, are administered intramuscularly and predominantly induce antigen expression in muscle cells, fibroblasts, and professional antigen presenting cells (APCs, including dendritic cells) present in germinal centers of the lymph nodes. These APCs are primed by direct adenovirus infection or by cross-priming from nonimmune cells.(38)
During vaccination, SARS-CoV-2 S protein processing can be dependent on both the receptors present on and the enzymes expressed by the S-producing cells.(39) Presence of the cell entry receptor ACE2 and host-cell proteases including furin and TMPRSS2 can drive conformational rearrangements resulting in postfusion conformations of S. Tissue distribution of ACE2 is primarily in the nasal mucosa and GI tracts, and TMPRSS2 is predominantly expressed in lungs and GI tracts, where cells are susceptible to SARS-CoV-2 infection. In contrast, the muscle, fibroblast, and immune cell types targeted by intramuscularly administered ChAdOx1 nCoV-19 have not been shown to express high levels of ACE2 or TMPRSS2."
https://pubs.acs.org/doi/10.1021/acscentsci.1c00080
ACS Publications
Native-like SARS-CoV-2 Spike Glycoprotein Expressed by ChAdOx1 nCoV-19/AZD1222 Vaccine
Vaccine development against the SARS-CoV-2 virus focuses on the principal target of the neutralizing immune response, the spike (S) glycoprotein. Adenovirus-vectored vaccines offer an effective platform for the delivery of viral antigen, but it is important…
Stop masks in schools
Experts give damning opinion of masks
Two expert reports have been served to the school's solicitors today (09 April 2021).
The opinions given are clear: requiring children to wear face coverings in schools is causing an immediate and ongoing risk of mental and physical harm to our children. Those harms may be of the most serious kind.
They make for shocking and upsetting reading.
To view theses MUST READ reports, click on the update tab and the links are there.
Retweet, with a quote from the report maybe, and email to anyone with children.
This must stop.
https://www.crowdjustice.com/case/stop-masks-in-schools/
Experts give damning opinion of masks
Two expert reports have been served to the school's solicitors today (09 April 2021).
The opinions given are clear: requiring children to wear face coverings in schools is causing an immediate and ongoing risk of mental and physical harm to our children. Those harms may be of the most serious kind.
They make for shocking and upsetting reading.
To view theses MUST READ reports, click on the update tab and the links are there.
Retweet, with a quote from the report maybe, and email to anyone with children.
This must stop.
https://www.crowdjustice.com/case/stop-masks-in-schools/
CrowdJustice
Stop masks in schools
Lawyers helping the public and business understand what is law and what is just guidance. We also provide a whistleblowing platform for teachers, NHS and all sectors. We ain't just whistling.
"In Denmark, only 0.5% of those tested are positive for COVID-19. Thus, for every 1000 people who are tested, we will get these results:
Infected, Healthy
Test +
5, 22
Test -
0, 973
This means that 81% (22/27) of those who are told they are ‘infected’ are actually healthy. A requirement for school attendance is a negative test twice a week, and in order to work at the Danish Technical University you must be able to present a Covid negative certificate, less than 72 hours old, to armed guards in the building.
In Denmark, in the last week of March, 1.1 million PCR tests were carried out (population of 5.8 million). Consequently, an enormous number of healthy people will be declared ill; they will be isolated; and many contacts will be asked to be tested, too. This situation is likely to spiral into chaos."
https://www.bmj.com/content/373/bmj.n861/rr#
Infected, Healthy
Test +
5, 22
Test -
0, 973
This means that 81% (22/27) of those who are told they are ‘infected’ are actually healthy. A requirement for school attendance is a negative test twice a week, and in order to work at the Danish Technical University you must be able to present a Covid negative certificate, less than 72 hours old, to armed guards in the building.
In Denmark, in the last week of March, 1.1 million PCR tests were carried out (population of 5.8 million). Consequently, an enormous number of healthy people will be declared ill; they will be isolated; and many contacts will be asked to be tested, too. This situation is likely to spiral into chaos."
https://www.bmj.com/content/373/bmj.n861/rr#
Facemasks in the COVID-19 era: A health hypothesis - ScienceDirect
"In addition to hypoxia and hypercapnia, breathing through facemask residues bacterial and germs components on the inner and outside layer of the facemask. These toxic components are repeatedly rebreathed back into the body, causing self-contamination. Breathing through facemasks also increases temperature and humidity in the space between the mouth and the mask, resulting a release of toxic particles from the mask’s materials [1], [2], [19], [26], [35], [36]. A systematic literature review estimated that aerosol contamination levels of facemasks including 13 to 202,549 different viruses [1]. Rebreathing contaminated air with high bacterial and toxic particle concentrations along with low O2 and high CO2 levels continuously challenge the body homeostasis, causing self-toxicity and immunosuppression [1], [2], [19], [26], [35], [36].
A study on 39 patients with renal disease found that wearing N95 facemask during hemodialysis significantly reduced arterial partial oxygen pressure (from PaO2 101.7 to 92.7 mm Hg), increased respiratory rate (from 16.8 to 18.8 breaths/min), and increased the occurrence of chest discomfort and respiratory distress [35]. Respiratory Protection Standards from Occupational Safety and Health Administration, US Department of Labor states that breathing air with O2 concentration below 19.5% is considered oxygen-deficiency, causing physiological and health adverse effects. These include increased breathing frequency, accelerated heartrate and cognitive impairments related to thinking and coordination [36]. A chronic state of mild hypoxia and hypercapnia has been shown as primarily mechanism for developing cognitive dysfunction based on animal studies and studies in patients with chronic obstructive pulmonary disease [44].
The adverse physiological effects were confirmed in a study of 53 surgeons where surgical facemask were used during a major operation. After 60 min of facemask wearing the oxygen saturation dropped by more than 1% and heart rate increased by approximately five beats/min [45]. Another study among 158 health-care workers using protective personal equipment primarily N95 facemasks reported that 81% (128 workers) developed new headaches during their work shifts as these become mandatory due to COVID-19 outbreak. For those who used the N95 facemask greater than 4 h per day, the likelihood for developing a headache during the work shift was approximately four times higher [Odds ratio = 3.91, 95% CI (1.35–11.31) p = 0.012], while 82.2% of the N95 wearers developed the headache already within ≤10 to 50 min [46]."
https://www.sciencedirect.com/science/article/pii/S0306987720333028
"In addition to hypoxia and hypercapnia, breathing through facemask residues bacterial and germs components on the inner and outside layer of the facemask. These toxic components are repeatedly rebreathed back into the body, causing self-contamination. Breathing through facemasks also increases temperature and humidity in the space between the mouth and the mask, resulting a release of toxic particles from the mask’s materials [1], [2], [19], [26], [35], [36]. A systematic literature review estimated that aerosol contamination levels of facemasks including 13 to 202,549 different viruses [1]. Rebreathing contaminated air with high bacterial and toxic particle concentrations along with low O2 and high CO2 levels continuously challenge the body homeostasis, causing self-toxicity and immunosuppression [1], [2], [19], [26], [35], [36].
A study on 39 patients with renal disease found that wearing N95 facemask during hemodialysis significantly reduced arterial partial oxygen pressure (from PaO2 101.7 to 92.7 mm Hg), increased respiratory rate (from 16.8 to 18.8 breaths/min), and increased the occurrence of chest discomfort and respiratory distress [35]. Respiratory Protection Standards from Occupational Safety and Health Administration, US Department of Labor states that breathing air with O2 concentration below 19.5% is considered oxygen-deficiency, causing physiological and health adverse effects. These include increased breathing frequency, accelerated heartrate and cognitive impairments related to thinking and coordination [36]. A chronic state of mild hypoxia and hypercapnia has been shown as primarily mechanism for developing cognitive dysfunction based on animal studies and studies in patients with chronic obstructive pulmonary disease [44].
The adverse physiological effects were confirmed in a study of 53 surgeons where surgical facemask were used during a major operation. After 60 min of facemask wearing the oxygen saturation dropped by more than 1% and heart rate increased by approximately five beats/min [45]. Another study among 158 health-care workers using protective personal equipment primarily N95 facemasks reported that 81% (128 workers) developed new headaches during their work shifts as these become mandatory due to COVID-19 outbreak. For those who used the N95 facemask greater than 4 h per day, the likelihood for developing a headache during the work shift was approximately four times higher [Odds ratio = 3.91, 95% CI (1.35–11.31) p = 0.012], while 82.2% of the N95 wearers developed the headache already within ≤10 to 50 min [46]."
https://www.sciencedirect.com/science/article/pii/S0306987720333028
Facemasks in the COVID-19 era: A health hypothesis - ScienceDirect
"Psychologically, wearing facemask fundamentally has negative effects on the wearer and the nearby person. Basic human-to-human connectivity through face expression is compromised and self-identity is somewhat eliminated [47], [48], [49]. These dehumanizing movements partially delete the uniqueness and individuality of person who wearing the facemask as well as the connected person [49]. Social connections and relationships are basic human needs, which innately inherited in all people, whereas reduced human-to-human connections are associated with poor mental and physical health [50], [51]. Despite escalation in technology and globalization that would presumably foster social connections, scientific findings show that people are becoming increasingly more socially isolated, and the prevalence of loneliness is increasing in last few decades [50], [52]. Poor social connections are closely related to isolation and loneliness, considered significant health related risk factors [50], [51], [52], [53].
A meta-analysis of 91 studies of about 400,000 people showed a 13% increased morality risk among people with low compare to high contact frequency [53]. Another meta-analysis of 148 prospective studies (308,849 participants) found that poor social relationships was associated with 50% increased mortality risk. People who were socially isolated or fell lonely had 45% and 40% increased mortality risk, respectively. These findings were consistent across ages, sex, initial health status, cause of death and follow-up periods"
https://www.sciencedirect.com/science/article/pii/S0306987720333028
"Psychologically, wearing facemask fundamentally has negative effects on the wearer and the nearby person. Basic human-to-human connectivity through face expression is compromised and self-identity is somewhat eliminated [47], [48], [49]. These dehumanizing movements partially delete the uniqueness and individuality of person who wearing the facemask as well as the connected person [49]. Social connections and relationships are basic human needs, which innately inherited in all people, whereas reduced human-to-human connections are associated with poor mental and physical health [50], [51]. Despite escalation in technology and globalization that would presumably foster social connections, scientific findings show that people are becoming increasingly more socially isolated, and the prevalence of loneliness is increasing in last few decades [50], [52]. Poor social connections are closely related to isolation and loneliness, considered significant health related risk factors [50], [51], [52], [53].
A meta-analysis of 91 studies of about 400,000 people showed a 13% increased morality risk among people with low compare to high contact frequency [53]. Another meta-analysis of 148 prospective studies (308,849 participants) found that poor social relationships was associated with 50% increased mortality risk. People who were socially isolated or fell lonely had 45% and 40% increased mortality risk, respectively. These findings were consistent across ages, sex, initial health status, cause of death and follow-up periods"
https://www.sciencedirect.com/science/article/pii/S0306987720333028
Facemasks in the COVID-19 era: A health hypothesis - ScienceDirect
"In normal conditions at the sea level, air contains 20.93% O2 and 0.03% CO2, providing partial pressures of 100 mmHg and 40 mmHg for these gases in the arterial blood, respectively. These gas concentrations significantly altered when breathing occurs through facemask. A trapped air remaining between the mouth, nose and the facemask is rebreathed repeatedly in and out of the body, containing low O2 and high CO2 concentrations, causing hypoxemia and hypercapnia [35], [36], [11], [12], [13]. Severe hypoxemia may also provoke cardiopulmonary and neurological complications and is considered an important clinical sign in cardiopulmonary medicine [37], [38], [39], [40], [41], [42]. Low oxygen content in the arterial blood can cause myocardial ischemia, serious arrhythmias, right or left ventricular dysfunction, dizziness, hypotension, syncope and pulmonary hypertension [43]. Chronic low-grade hypoxemia and hypercapnia as result of using facemask can cause exacerbation of existing cardiopulmonary, metabolic, vascular and neurological conditions [37], [38], [39], [40], [41], [42]. Table 1 summarizes the physiological, psychological effects of wearing facemask and their potential long-term consequences for health."
https://www.sciencedirect.com/science/article/pii/S0306987720333028
"In normal conditions at the sea level, air contains 20.93% O2 and 0.03% CO2, providing partial pressures of 100 mmHg and 40 mmHg for these gases in the arterial blood, respectively. These gas concentrations significantly altered when breathing occurs through facemask. A trapped air remaining between the mouth, nose and the facemask is rebreathed repeatedly in and out of the body, containing low O2 and high CO2 concentrations, causing hypoxemia and hypercapnia [35], [36], [11], [12], [13]. Severe hypoxemia may also provoke cardiopulmonary and neurological complications and is considered an important clinical sign in cardiopulmonary medicine [37], [38], [39], [40], [41], [42]. Low oxygen content in the arterial blood can cause myocardial ischemia, serious arrhythmias, right or left ventricular dysfunction, dizziness, hypotension, syncope and pulmonary hypertension [43]. Chronic low-grade hypoxemia and hypercapnia as result of using facemask can cause exacerbation of existing cardiopulmonary, metabolic, vascular and neurological conditions [37], [38], [39], [40], [41], [42]. Table 1 summarizes the physiological, psychological effects of wearing facemask and their potential long-term consequences for health."
https://www.sciencedirect.com/science/article/pii/S0306987720333028
Facemasks in the COVID-19 era: A health hypothesis - ScienceDirect
"The data suggest that both medical and non-medical facemasks are ineffective to block human-to-human transmission of viral and infectious disease such SARS-CoV-2 and COVID-19, supporting against the usage of facemasks. Wearing facemasks has been demonstrated to have substantial adverse physiological and psychological effects. These include hypoxia, hypercapnia, shortness of breath, increased acidity and toxicity, activation of fear and stress response, rise in stress hormones, immunosuppression, fatigue, headaches, decline in cognitive performance, predisposition for viral and infectious illnesses, chronic stress, anxiety and depression. Long-term consequences of wearing facemask can cause health deterioration, developing and progression of chronic diseases and premature death."
https://www.sciencedirect.com/science/article/pii/S0306987720333028
"The data suggest that both medical and non-medical facemasks are ineffective to block human-to-human transmission of viral and infectious disease such SARS-CoV-2 and COVID-19, supporting against the usage of facemasks. Wearing facemasks has been demonstrated to have substantial adverse physiological and psychological effects. These include hypoxia, hypercapnia, shortness of breath, increased acidity and toxicity, activation of fear and stress response, rise in stress hormones, immunosuppression, fatigue, headaches, decline in cognitive performance, predisposition for viral and infectious illnesses, chronic stress, anxiety and depression. Long-term consequences of wearing facemask can cause health deterioration, developing and progression of chronic diseases and premature death."
https://www.sciencedirect.com/science/article/pii/S0306987720333028