🩺 MEDLAB BOT AI • CLINICAL MLS MCQ
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📚 Specialty: Hematology & Clinical Microscopy (#HematologyampClinicalMicroscopy)
🎯 Difficulty: Intermediate
🔢 Item: #Q11

❓ QUESTION:
A 58-year-old male presents with marked splenomegaly and severe leukocytosis (WBC 115,000/µL). Peripheral blood differential displays a continuous granulocytic maturation spectrum: 2% myeloblasts, 3% promyelocytes, 22% myelocytes, 16% metamyelocytes, 18% bands, 32% segmented neutrophils, 4% basophils, and 3% eosinophils. The Leukocyte Alkaline Phosphatase (LAP) score is markedly decreased at 8 (Reference range: 20–100). Which genetic translocational driver confirms this diagnosis?

A) t(9;22)(q34.1;q11.2) forming BCR-ABL1
B) t(15;17)(q24.1;q21.2) forming PML-RARA
C) t(8;14)(q24;q32) forming MYC-IGH
D) t(11;14)(q13;q32) forming CCND1-IGH

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✅ CORRECT ANSWER: Option A

💡 CLINICAL RATIONALE & DIAGNOSTIC PEARLS:
The clinical picture of marked granulocytic leukocytosis with all stages of myeloid maturation, absolute basophilia, splenomegaly, and a dramatically decreased LAP score is classic for Chronic Myeloid Leukemia (CML) in chronic phase. CML is defined by the reciprocal translocation t(9;22)(q34.1;q11.2), creating the Philadelphia chromosome and the constitutive tyrosine kinase fusion gene BCR-ABL1.

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📢 MedLab Bot AI • Official Clinical Series