SARS-CoV-2 spike S2 subunit inhibits p53 activation of p21(WAF1), TRAIL Death Receptor DR5 and MDM2 proteins in cancer cells
"Our results have implications for the biological effects of spike S2 subunit in human cells whether spike is present due to primary COVID-19 infection or due to mRNA vaccines where its expression is used to promote anti-viral immunity. A perturbed p53 pathway is concerning but also complicated in sorting out since cellular transformation and cancer are a multi-step process that evolves over time. Further detailed studies can more fully characterize the effects of spike, as well as structural determinants within the protein for interaction between the DNA damage sensing and response pathways as well as the p53 tumor suppressing pathway. With respect to the p53 pathway, further studies are needed to unravel how less MDM2 is bound to p53 in the presence of spike and the mechanisms underlying reduced p21(WAF10), TRAIL Death Receptor DR5 as well as MDM2 under conditions where there is less degradation of p53 due to reduced interaction with MDM2."
https://www.biorxiv.org/content/10.1101/2024.04.12.589252v1
"Our results have implications for the biological effects of spike S2 subunit in human cells whether spike is present due to primary COVID-19 infection or due to mRNA vaccines where its expression is used to promote anti-viral immunity. A perturbed p53 pathway is concerning but also complicated in sorting out since cellular transformation and cancer are a multi-step process that evolves over time. Further detailed studies can more fully characterize the effects of spike, as well as structural determinants within the protein for interaction between the DNA damage sensing and response pathways as well as the p53 tumor suppressing pathway. With respect to the p53 pathway, further studies are needed to unravel how less MDM2 is bound to p53 in the presence of spike and the mechanisms underlying reduced p21(WAF10), TRAIL Death Receptor DR5 as well as MDM2 under conditions where there is less degradation of p53 due to reduced interaction with MDM2."
https://www.biorxiv.org/content/10.1101/2024.04.12.589252v1
bioRxiv
SARS-CoV-2 spike S2 subunit inhibits p53 activation of p21(WAF1), TRAIL Death Receptor DR5 and MDM2 proteins in cancer cells
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and COVID-19 infection has led to worsened outcomes for patients with cancer. SARS-CoV-2 spike protein mediates host cell infection and cell-cell fusion that causes stabilization of tumor suppressor…
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🤩UNGLAUBLICHES bei LANZ!!!
Und hätte ich es nicht selbst 👀GESEHEN & GEHÖRT👂🏼, ich hätte NICHT geglaubt, dass es jemals SOO im ÖRR ausgestrahlt wurde!!👏👏
💣BQQMS💣
https://t.me/TiQToQBQQms
Und hätte ich es nicht selbst 👀GESEHEN & GEHÖRT👂🏼, ich hätte NICHT geglaubt, dass es jemals SOO im ÖRR ausgestrahlt wurde!!👏👏
💣BQQMS💣
https://t.me/TiQToQBQQms
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Annelise hat es endlich geschafft und dieses Paper publiziert!
Impact of the SARS-CoV-2 Spike Protein on the Innate Immune System: A Review
"Not only can Spike itself be amyloid, but it can also interact with other amyloid fibers; notably the S1 subunit can bind Aβ42. This S1/Aβ42 interaction appears to increase the production of IL-6, one of the most abundant proinflammatory cytokines found in severe forms of COVID-19, via activation of ACE2. In fact, binding with Aβ42 does not impede the S1 subunit from binding with its receptor."
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10973921/
Oh man, Fibronectin und Fibronogen sind so furchteinflößend kompliziert prozessierte Proteinkomplexe. Ich erinnere mich an die Fibronectinlektion in Wehner und Gehring - Zoologie. :-S
Impact of the SARS-CoV-2 Spike Protein on the Innate Immune System: A Review
"Not only can Spike itself be amyloid, but it can also interact with other amyloid fibers; notably the S1 subunit can bind Aβ42. This S1/Aβ42 interaction appears to increase the production of IL-6, one of the most abundant proinflammatory cytokines found in severe forms of COVID-19, via activation of ACE2. In fact, binding with Aβ42 does not impede the S1 subunit from binding with its receptor."
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10973921/
Oh man, Fibronectin und Fibronogen sind so furchteinflößend kompliziert prozessierte Proteinkomplexe. Ich erinnere mich an die Fibronectinlektion in Wehner und Gehring - Zoologie. :-S
PubMed Central (PMC)
Impact of the SARS-CoV-2 Spike Protein on the Innate Immune System: A Review
The Spike protein enables the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection by binding to multiple receptors, including the angiotensin-converting enzyme 2 (ACE2). Scientific studies also indicate that Spike is involved in severe…
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Und wenn wir schon bei Schwärzungen sind:
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Ich könnte gerade loskotzen.
Forwarded from Eva Herman Offiziell
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‼️ 👉 AfD MdB Beatrix von Storch:
"Der #WHO-Pandemievertrag liegt vor: das Multi-Milliarden-bedingungslose Grundeinkommen für Pfizer, Biontech & Co. ist da geplant. Hören! Teilen! Widerstand mobilisieren!"
https://x.com/Beatrix_vStorch/status/1780243467920105979
"Der #WHO-Pandemievertrag liegt vor: das Multi-Milliarden-bedingungslose Grundeinkommen für Pfizer, Biontech & Co. ist da geplant. Hören! Teilen! Widerstand mobilisieren!"
https://x.com/Beatrix_vStorch/status/1780243467920105979