https://pubs.acs.org/ancac3/article/13/8/8749/808496/Patchy-Amphiphilic-Dendrimers-Bind-Adenovirus-and
OOPS! AAVs bilden also auch eine Proteincorona (wenn auch wesentlich spezifischer durch Antikörper und Komplementsystem)...
OOPS! AAVs bilden also auch eine Proteincorona (wenn auch wesentlich spezifischer durch Antikörper und Komplementsystem)...
ACS Publications
Patchy
Amphiphilic Dendrimers Bind Adenovirus and
Control Its Host Interactions and in Vivo Distribution
Amphiphilic Dendrimers Bind Adenovirus and
Control Its Host Interactions and in Vivo Distribution
Abstract. The
surface of proteins is heterogeneous with sophisticated but
precise hydrophobic and hydrophilic patches, which is essential for
their diverse
surface of proteins is heterogeneous with sophisticated but
precise hydrophobic and hydrophilic patches, which is essential for
their diverse
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Forwarded from News von TKP
Senator Rand Paul hat es getan. Der Vorsitzende des Homeland-Security-Ausschusses im Senat veröffentlichte am Wochenende über 1.100 Seiten privater Tagebucheinträge von Anthony Fauci — pünktlich vor dessen für Mittwoch angesetzter Aussage vor dem Senat.
Beitrag hier lesen👇
https://tkp.at/2026/07/28/faucis-tagebuch-groessenwahn-medienkumpanei-und-die-lab-leak-luege/
Beitrag hier lesen👇
https://tkp.at/2026/07/28/faucis-tagebuch-groessenwahn-medienkumpanei-und-die-lab-leak-luege/
tkp.at
Faucis Tagebuch: Größenwahn, Medienkumpanei und die Lab-Leak-Lüge
Senator Rand Paul hat es getan. Der Vorsitzende des Homeland-Security-Ausschusses im Senat veröffentlichte am Wochenende über 1.100 Seiten privater Tagebucheinträge von Anthony Fauci — pünktlich vor dessen für Mittwoch angesetzter[…]
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News von TKP
Senator Rand Paul hat es getan. Der Vorsitzende des Homeland-Security-Ausschusses im Senat veröffentlichte am Wochenende über 1.100 Seiten privater Tagebucheinträge von Anthony Fauci — pünktlich vor dessen für Mittwoch angesetzter Aussage vor dem Senat. Beitrag…
Homeland Security schon auf Youtube abonniert für das Hearing am Mittwoch. *_*
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We have checked and there is little to no spike protein found in the plasma, and I think the high AB production comes from failure of apoptotic pathways that cause neutrophils to remain in circulation after exposure to spike protein, this leads to sustained immune activation, and subsequent high AB levels as response.
https://x.com/kevinmccairnphd/status/2081869210809217062?s=52&t=fHNy04S5p-78vK_ah9g3hw
Witzig! McCairn räumt es selbst ein, aber schlussfolgert natürlich völlig Banane und wirres Zeugs.
Reminder:
"Because PEG triggers initial IgM release by directly crosslinking B-cell receptors in the spleen81, IgM can be measured ex vivo even in the absence of intact splenic architecture82. We observed that blocking inflammatory signaling with either TAK-242 or 20H2 increased anti-PEG IgM production increased for splenocytes treated with 304 LNPs in the presence of 20H2 (Fig. 6H). Next, to confirm that a similar phenomenon occurs in vivo, we injected mice with 304Oi10 and 306Oi10 LNPs along with CD1d and TLR4 inhibitors and corresponding isotype and solvent controls. Indeed, CD1d and TLR4 blockade caused a significant increase in PEG-IgM (Fig. 6I, S15A) and PEG-IgG antibodies (Fig. 6J, S15B). "
Chaudhary N, Kasiewicz LN, Newby AN, Arral ML, Yerneni SS, Melamed JR, LoPresti ST, Fein KC, Strelkova Petersen DM, Kumar S, Purwar R, Whitehead KA. Amine headgroups in ionizable lipids drive immune responses to lipid nanoparticles by binding to the receptors TLR4 and CD1d. Nat Biomed Eng. 2024 Nov;8(11):1483-1498. doi: 10.1038/s41551-024-01256-w. Epub 2024 Oct 3. PMID: 39363106; PMCID: PMC11863198.
"These vaccines utilize four-component lipid nanoparticles (LNPs) that have been shown to potently induce IL-1, IL-6 secretion, TFH and GC B cell generation in humans1,10,36,37,38. "
Connors, J., Joyner, D., Mege, N.J. et al. Lipid nanoparticles (LNP) induce activation and maturation of antigen presenting cells in young and aged individuals. Commun Biol 6, 188 (2023). doi: 10.1038/s42003-023-04555-1
Nguyen H, Alexander K, Collinge M, et al., mRNA-LNPs induce immune activation and cytokine release in human whole blood assays across diverse health conditions Molecular Therapy, DOI: 10.1016/j.ymthe.2024.12.019; 33, 2872-2885
Qin Z, Bouteau A, Herbst C, Igyártó BZ. Pre-exposure to mRNA-LNP inhibits adaptive immune responses and alters innate immune fitness in an inheritable fashion. bioRxiv [Preprint]. 2022 Aug 20:2022.03.16.484616. doi: 10.1101/2022.03.16.484616. Update in: PLoS Pathog. 2022 Sep 2;18(9):e1010830. doi: 10.1371/journal.ppat.1010830. PMID: 36032972; PMCID: PMC9413714
Ich mag den hier:
https://x.com/surf4children/status/2081877785442705624
Narf!
https://x.com/kevinmccairnphd/status/2081869210809217062?s=52&t=fHNy04S5p-78vK_ah9g3hw
Witzig! McCairn räumt es selbst ein, aber schlussfolgert natürlich völlig Banane und wirres Zeugs.
Reminder:
"Because PEG triggers initial IgM release by directly crosslinking B-cell receptors in the spleen81, IgM can be measured ex vivo even in the absence of intact splenic architecture82. We observed that blocking inflammatory signaling with either TAK-242 or 20H2 increased anti-PEG IgM production increased for splenocytes treated with 304 LNPs in the presence of 20H2 (Fig. 6H). Next, to confirm that a similar phenomenon occurs in vivo, we injected mice with 304Oi10 and 306Oi10 LNPs along with CD1d and TLR4 inhibitors and corresponding isotype and solvent controls. Indeed, CD1d and TLR4 blockade caused a significant increase in PEG-IgM (Fig. 6I, S15A) and PEG-IgG antibodies (Fig. 6J, S15B). "
Chaudhary N, Kasiewicz LN, Newby AN, Arral ML, Yerneni SS, Melamed JR, LoPresti ST, Fein KC, Strelkova Petersen DM, Kumar S, Purwar R, Whitehead KA. Amine headgroups in ionizable lipids drive immune responses to lipid nanoparticles by binding to the receptors TLR4 and CD1d. Nat Biomed Eng. 2024 Nov;8(11):1483-1498. doi: 10.1038/s41551-024-01256-w. Epub 2024 Oct 3. PMID: 39363106; PMCID: PMC11863198.
"These vaccines utilize four-component lipid nanoparticles (LNPs) that have been shown to potently induce IL-1, IL-6 secretion, TFH and GC B cell generation in humans1,10,36,37,38. "
Connors, J., Joyner, D., Mege, N.J. et al. Lipid nanoparticles (LNP) induce activation and maturation of antigen presenting cells in young and aged individuals. Commun Biol 6, 188 (2023). doi: 10.1038/s42003-023-04555-1
Nguyen H, Alexander K, Collinge M, et al., mRNA-LNPs induce immune activation and cytokine release in human whole blood assays across diverse health conditions Molecular Therapy, DOI: 10.1016/j.ymthe.2024.12.019; 33, 2872-2885
Qin Z, Bouteau A, Herbst C, Igyártó BZ. Pre-exposure to mRNA-LNP inhibits adaptive immune responses and alters innate immune fitness in an inheritable fashion. bioRxiv [Preprint]. 2022 Aug 20:2022.03.16.484616. doi: 10.1101/2022.03.16.484616. Update in: PLoS Pathog. 2022 Sep 2;18(9):e1010830. doi: 10.1371/journal.ppat.1010830. PMID: 36032972; PMCID: PMC9413714
Ich mag den hier:
https://x.com/surf4children/status/2081877785442705624
Narf!
😁1
https://www.youtube.com/watch?v=KCZGHKO6N3Y
OMG! Paul hat Fauci an den ****! Er verweigert jede Aussage!
LIVE!
OMG! Paul hat Fauci an den ****! Er verweigert jede Aussage!
LIVE!
YouTube
REPLAY: Homeland Security and Governmental Affairs Hearing on Anthony Fauci Testimony - 7/29/26
Watch RSBN LIVE for complete coverage of the committee hearing on the testimony of Anthony Fauci.
Tune in at 8:30 am EDT on July 29, 2026.
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Tune in at 8:30 am EDT on July 29, 2026.
10% Off Everything at All Family Pharmacy
Use code: RSBN10
https://allfamilypharmacy.com/rsbn
Learn why many Americans…
Forwarded from henning rosenbusch - Channel
Die „Corona-Bekämpfer“ der 3a erhielten Urkunden.
Weil sich die acht bis neunjährigen Kinder mindestens fünf mal „freiwillig“ testen ließen.
#RichtigErinnern
t.me/Rosenbusch
Weil sich die acht bis neunjährigen Kinder mindestens fünf mal „freiwillig“ testen ließen.
#RichtigErinnern
t.me/Rosenbusch
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Ich bin heute in totaler Arschlochlaune und überlege, ob ich diesem Professor nen echten Seitenhieb via E-Mail verpassen sollte:
"Dear Professor Abd El-Aty,
I hope you are doing well.
Last year, you handled our submission entitled "Lipid Nanoparticles as Active Biointerfaces: From Membrane Interaction to Systemic Dysregulation."
Although the manuscript was not accepted at that time, I would like to thank you for considering our work.
Since then, the manuscript has undergone a thorough peer-review process at another journal. The reviewers provided detailed and constructive comments that helped us further refine the scientific presentation, strengthen the discussion of the evidence, and improve the overall clarity of the manuscript. We are pleased to share that the revised manuscript has now been accepted for publication in Acta Pharmaceutica Sinica B:
Seger, F., Gutschi, L.M., Seneff, S. (2026). Lipid Nanoparticles as Active Biointerfaces: From Membrane Interaction to Systemic Dysregulation. Acta Pharmaceutica Sinica B.
https://doi.org/10.1016/j.apsb.2026.07.001
Looking back, I particularly valued the experience of a peer-review process that engaged deeply with the scientific content of the manuscript and contributed substantially to its improvement.
With best regards,
Falko Seger"
(Den Screenshot würde ich als JPG noch anhängen. XD)
"Dear Professor Abd El-Aty,
I hope you are doing well.
Last year, you handled our submission entitled "Lipid Nanoparticles as Active Biointerfaces: From Membrane Interaction to Systemic Dysregulation."
Although the manuscript was not accepted at that time, I would like to thank you for considering our work.
Since then, the manuscript has undergone a thorough peer-review process at another journal. The reviewers provided detailed and constructive comments that helped us further refine the scientific presentation, strengthen the discussion of the evidence, and improve the overall clarity of the manuscript. We are pleased to share that the revised manuscript has now been accepted for publication in Acta Pharmaceutica Sinica B:
Seger, F., Gutschi, L.M., Seneff, S. (2026). Lipid Nanoparticles as Active Biointerfaces: From Membrane Interaction to Systemic Dysregulation. Acta Pharmaceutica Sinica B.
https://doi.org/10.1016/j.apsb.2026.07.001
Looking back, I particularly valued the experience of a peer-review process that engaged deeply with the scientific content of the manuscript and contributed substantially to its improvement.
With best regards,
Falko Seger"
(Den Screenshot würde ich als JPG noch anhängen. XD)
😁4
Retrospektiv betrachtet, haben wir zwischen 2,500 - 10,000 USD gespart und nen fast 4fachen Impactfactor abgestaubt im 5 Jahresschnitt. Und wir vermieden ein Journal, das eindeutig gegen COPE-Richtlinien verstößt und bekamen als Sahnebonbon großartige Reviewer, die das Potenzial sahen und begriffen, wovon wir schreiben.
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Viel Spaß beim Lesen: Das ist brutal!
https://genervter.substack.com/p/compensation-and-time
ttps://mariagutschi.substack.com/p/four-questions-about-mrna-lnp-vaccines
https://x.com/stephanieseneff/status/2082298352017043646?s=52
https://genervter.substack.com/p/compensation-and-time
ttps://mariagutschi.substack.com/p/four-questions-about-mrna-lnp-vaccines
https://x.com/stephanieseneff/status/2082298352017043646?s=52
Substack
Compensation and time
Time cannot be replaced by prestige, hubris, and advertising