⭕️ The effect of different #carbapenem antibiotics (ertapenem, imipenem/cilastatin and meropenem) on serum #valproic acid concentrations.
⭕️ معلومة #هامة جدا و يجب الانتباه لها ..
دواء الCarbapenem ( مضاد حيوي ) عند استخدامه مع دواء ال Valproic acid .. فإنه يسبب انخفاض في نسبة الValproic Acid
و هنا يضطر الطبيب المعالج لزيادة جرعة الValproic acid ..
و من الأفضل تجنب تناول الدوايين الاثنين معا ..
⭕️ Therapeutic Drug Monitoring
Post Acceptance: June 15, 2016
⭕️ Background: Carbapenem antibiotics (CBPMs) may significantly reduce the serum concentration of valproic acid (VPA), but the extent of this effect among various CBPMs is unknown. This study compared the extent and onset of the interactions among ertapenem, imipenem/cilastatin, and meropenem.
⭕️ Conclusions: CBPMs reduced VPA serum concentration within 24 hours of administration by approximately 60%. Ertapenem and meropenem had a greater effect on VPA serum concentration than imipenem/cilastatin. Because of the dramatic reduction of VPA serum concentration during CBPMs' use, concomitant use of VPA and CBPMs should be avoided.
⭕️ Reference:
2016 Wolters Kluwer Health.
⭕️ معلومة #هامة جدا و يجب الانتباه لها ..
دواء الCarbapenem ( مضاد حيوي ) عند استخدامه مع دواء ال Valproic acid .. فإنه يسبب انخفاض في نسبة الValproic Acid
و هنا يضطر الطبيب المعالج لزيادة جرعة الValproic acid ..
و من الأفضل تجنب تناول الدوايين الاثنين معا ..
⭕️ Therapeutic Drug Monitoring
Post Acceptance: June 15, 2016
⭕️ Background: Carbapenem antibiotics (CBPMs) may significantly reduce the serum concentration of valproic acid (VPA), but the extent of this effect among various CBPMs is unknown. This study compared the extent and onset of the interactions among ertapenem, imipenem/cilastatin, and meropenem.
⭕️ Conclusions: CBPMs reduced VPA serum concentration within 24 hours of administration by approximately 60%. Ertapenem and meropenem had a greater effect on VPA serum concentration than imipenem/cilastatin. Because of the dramatic reduction of VPA serum concentration during CBPMs' use, concomitant use of VPA and CBPMs should be avoided.
⭕️ Reference:
2016 Wolters Kluwer Health.