https://www.youtube.com/watch?v=uX5JF35kEgQ

Danke, Klaus. ♥️

Dowd: Zahl der Menschen mit Behinderung in den USA erreicht im Juli mit 37 Millionen einen neuen Höchststand: Anstieg um 23 % seit Februar 2021

Von Tyler Durden

Verfasst von Ed Dowd via Beyond The Narrative,

Die neuesten Daten des Bureau of Labor Statistics liegen vor, und die Zahl der Amerikaner ab 16 Jahren, die eine…

https://uncutnews.ch/dowd-zahl-der-menschen-mit-behinderung-in-den-usa-erreicht-im-juli-mit-37-millionen-einen-neuen-hoechststand-anstieg-um-23-seit-februar-2021/

🔴 Nichts verpassen 📬⚡️Abo → @uncut_news

🔴 Spenden: https://uncutnews.ch/kontakt/ DANKE ❤️

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High-Profile Departures Shake Up WHO Leadership, ‘Controversial’ Appointee Returns

https://healthpolicy-watch.news/high-profile-departures-who-leadership/

Top British scientist steps down from WHO

Exclusive: Sir Jeremy Farrar, who advised the government on Covid, resigns after helping to implement job cuts at global body

https://www.telegraph.co.uk/global-health/science-and-disease/top-uk-scientist-steps-down-from-who/

Erstes Substack von Rantanplan.
😊
Anderes Thema, trotzdem interessant.

https://rantanplan2.substack.com/p/ein-stilles-verbrechen-an-der-landschaft?r=6ogofm&utm_campaign=post-expanded-share&utm_medium=web

In Italien weiß niemand was von Hitzetoten oder Übersterblichkeit.

Muss eine andere Hitze-Variante sein oder es hat noch niemand Bescheid gesagt.

In Rom ist es im Juli/August übrigens durchschnittlich 7 Grad wärmer als in Deutschland.

https://www.deutschlandfunk.de/viel-zustimmung-fuer-hitzeschutz-vorschlaege-der-spd-union-weiterhin-skeptisch-102.html

t.me/Rosenbusch

27 injections for $500,000 and zero long term evidence of benefit-
Moderna Melanoma “vaccine”.

Korrektur
(Danke Klaus)

Das stimmt so nicht: Es sind wohl 9 mRNA-Injektionen für das gesamte Protokoll. Dazu kommen 18 Dosen Pembrolizumab. In neueren Protokollen wohl auch nur noch 9x Pembrolizumab. Der Preis soll auch noch nicht feststehen.

https://www.merck.com/news/mrna-4157-v940-an-investigational-personalized-mrna-cancer-vaccine-in-combination-with-keytruda-pembrolizumab-receives-prime-scheme-designation-from-the-european-medicines-agency-for-adjuva/

Ente, Hund, Maus, Ratte, Mensch: Fragen Sie Shizer... Alles das selbe! Sehen Sie?

*seufz* SOOOOO MÜÜÜÜÜÜÜÜDEEEEEEEEEEE!

Two-dimensional AEX – IP-RPLC: New insights on mRNA integrity and encapsulation efficiency of mRNA-lipid nanoparticle formulations

"Encapsulation efficiency (EE) and mRNA integrity are particularly critical, yet current analytical approaches often require separate assays, challenging sample handling, and limited selectivity toward free versus encapsulated species. Therefore, new chromatographic methods capable of resolving these species and supporting multi-payload formulations remain a major unmet need."

"The most widely used strategy to determine EE is a fluorescence-based assay usually employing the RiboGreen dye. Although this method is widely used, it has limitations. First, the use of the manual protocol is labor-intensive, and it often involves significant dilutions of the samples that can alter the structure of some LNPs. Secondly, because it relies on mRNA-dye biding, it is highly sensitive to matrix effects such as pH, ionic strength, buffer composition, and dilution [3,4]. As a novel alternative, Maurer et al. utilized hydrophilic interaction chromatography (HILIC) to measure EE under two mobile phase conditions: intact separation and online LNP disruption [5]. However, they noted robustness issues and pore-size mismatches in HILIC relative to the hydrodynamic radii of large mRNA species. Gao et al. proposed using asymmetrical flow field-flow fractionation (AF4) to measure encapsulation efficiency in a single injection [6]. AF4 separates molecules by hydrodynamic size using crossflow in a thin channel. However, implementation can be challenging due to recovery issues and complex instrumentation. Analytical ultracentrifugation has also shown promising results, opening new avenues for EE determinations [7]. Finally, ion exchange chromatography has been proposed, separating LNPs and mRNA based on charge differences [8,9]. This technique was shown to provide robust and reproducible measurements and mitigated specificity issues. In their study, Tsalmpouris et al. emphasized that AEX could give information on the localization of mRNA on the surface of LNPs, improving the understanding of mRNA-LNP formulation [9]."

https://www.sciencedirect.com/science/article/pii/S0003267026001650

Ich, in dem Falle Nicole, habe gerade einen unglaublich perfekten Buchtitel gefunden und Ulf Poschardt vorgeschlagen, er solle es schreiben, ansonsten müsste ich es tun. Wahrscheinlich läuft es darauf hinaus:

"Finally, we also showed the side effects of dysfunctional BM niche macrophages on hematopoiesis in mice, such as the promotion of myeloid-biased output and impairment of erythropoiesis. This study not only draws attention to the safety of liposomal drugs in clinical practice but also provides new directions for the design of lipid-based drug carriers in preclinical studies."

https://www.jlr.org/article/S0022-2275(22)00106-7/fulltext